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(Journal Article): The beta cell in autoimmune diabetes: many mechanisms and pathways of loss.
Kay TW, Thomas HE, Harrison LC, Allison J (Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia.)
IN:
Trends Endocrinol Metab
2000; 11(1):11-15
Impact Factor(s) of Trends Endocrinol Metab: 9.058 (2004), 7.85 (2003), 5.823 (2001)
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ABSTRACT: Death of pancreatic beta cells is the final step in the pathogenesis of type 1 diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to the clinical problem of diabetes is a current opportunity and challenge. To date, perforin is the only factor definitely implicated in beta-cell killing in the non-obese diabetic (NOD) mouse model, although some perforin-deficient NOD mice develop diabetes. Our results suggest that other factors that cause beta-cell death remain to be identified.
TYPE OF PUBLICATION: Review
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