41. (Journal Article): In vitro differentiation of embryonic stem cells.

Keller GM
 
ABSTRACT: Under appropriate conditions in culture, embryonic stem cells will differentiate and form embryoid bodies that have been shown to contain cells of the hematopoietic, endothelial, m...

42. (Journal Article): A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C
 
ABSTRACT: Previous linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was...

43. (Journal Article): T cell regulation: a special job or everyone's responsibility?

Stockinger B, Barthlott T, Kassiotis G
 
ABSTRACT: Not available

44. (Journal Article): Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets.

Abernethy DR, Soldatov NM
 
ABSTRACT: The L-type Ca2+ channels mediate depolarization-induced influx of Ca2+ into a wide variety of cells and thus play a central role in triggering cardiac and smooth muscle contraction...

45. (Journal Article): Adherence to Guidelines and its Effects on Hospitalizations with Complications of Type 2 Diabetes

Sloan FA, Bethel MA, Lee PP, Brown DS, Feinglos MN
 
ABSTRACT: OBJECTIVES: To study the discrepancy between actual and recommended rates of use among several measures of screening for complications of diabetes in a national longitudinal sample...

46. (Journal Article): Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells.

Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM
 
ABSTRACT: Insulin-expressing beta cells, found in pancreatic islets, are capable of generating more beta cells even in the adult. We show that fibroblast-like cells derived from adult human ...

47. (Journal Article): Neuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse.

Homo-Delarche F
 
ABSTRACT: Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which insulin-producing beta cells of the pancreatic islets of Langerhans are destroyed. The nonobese diabetic (NOD...

48. (Journal Article): Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets

Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R
 
ABSTRACT: Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead to many clinical benefits if differentiated cell types can be derived from them and u...

49. (Journal Article): CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.

Thornton AM, Shevach EM
 
ABSTRACT: Peripheral tolerance may be maintained by a population of regulatory/suppressor T cells that prevent the activation of autoreactive T cells recognizing tissue-specific antigens. We...

50. (Journal Article): Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM
 
ABSTRACT: CD4+CD25+ regulatory T cells (Treg) are instrumental in the maintenance of immunological tolerance. One critical question is whether Treg can only be generated in the thymus or can...