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Hypoxia
(Journal Article): Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression.
Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M
IN:
FASEB J
2002; 16(7):745–747.-
Impact Factor(s) of FASEB J: 6.82 (2004), 7.172 (2003), 8.817 (2001)
ABSTRACT:
To become insulin independent, patients with type 1 diabetes mellitus require transplantation of at least two donor pancreata because of massive beta-cell loss in the early post-tr...
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(Journal Article): Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion.
Dupraz P, Rinsch C, Pralong WF, Rolland E, Zufferey R, Trono D, Thorens B
IN:
Gene Ther
1999; 6(6):1160–1169.-
Impact Factor(s) of Gene Ther: 4.977 (2004), 5.293 (2003), 5.616 (2002), 5.893 (2001)
ABSTRACT:
betaTC-tet cells are conditionally immortalized pancreatic beta cells which can confer long-term correction of hyperglycemia when transplanted in syngeneic streptozocin diabetic mi...
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(Journal Article): Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
Grey ST, Longo C, Shukri T, Patel VI, Csizmadia E, Daniel S, Arvelo MB, Tchipashvili V, Ferran C
IN:
J Immunol
2003; 170(12):6250–6256.-
Impact Factor(s) of J Immunol: 6.486 (2004), 6.702 (2003), 7.065 (2001)
ABSTRACT:
Transplantation of an excessive number of islets of Langerhans (two to four pancreata per recipient) into patients with type I diabetes is required to restore euglycemia. Hypoxia, ...
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(Journal Article): XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury.
Emamaullee JA, Liston P, Korneluk RG, Shapiro AM, Elliott J
IN:
Am J Transplant
2005; 5(6):1297–1305
Impact Factor(s) of Am J Transplant: 5.306 (2004), 5.678 (2003)
ABSTRACT:
Recent advances in clinical islet transplantation have allowed patients with type 1 diabetes to become insulin independent, but the procedure is limited since islets from two donor...
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