In Vitro Derivation and Differentiation of Human ESC
Sub-Areas to In Vitro Derivation and Differentiation of Human ESC:
Growth Factors
(1)
(Journal Article): Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro.
Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A
IN:
Nat Biotech
2000; 18(4):399-404
ABSTRACT:
We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maint...
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(Journal Article): Derivation of pluripotent stem cells from cultured human primordial germ cells.
Shamblott MJ, Axelman J, Wang S, Bugg EM, Littlefield JW, Donovan PJ, Blumenthal PD, Huggins GR, Gearhart JD
IN:
Proc Natl Acad Sci U S A
1998; 95(23):13726-13731
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)
ABSTRACT:
Human pluripotent stem cells would be invaluable for in vitro studies of aspects of human embryogenesis. With the goal of establishing pluripotent stem cell lines, gonadal ridges a...
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(Journal Article): Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro.
Shamblott MJ, Axelman J, Littlefield JW, Blumenthal PD, Huggins GR, Cui Y, Cheng L, Gearhart JD
IN:
Proc Natl Acad Sci U S A
2001; 98(1):113-118
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)
ABSTRACT:
Human pluripotent stem cells (hPSCs) have been derived from the inner cell mass cells of blastocysts (embryonic stem cells) and primordial germ cells of the developing gonadal ridg...
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(Journal Article): In vitro differentiation of embryonic stem cells.
Keller GM
IN:
Curr Opin Cell Biol
1995; 7(6):862-869
Impact Factor(s) of Curr Opin Cell Biol: 15.422 (2004), 18.176 (2003), 19.022 (2002), 21.568 (2001)
ABSTRACT:
Under appropriate conditions in culture, embryonic stem cells will differentiate and form embryoid bodies that have been shown to contain cells of the hematopoietic, endothelial, m...
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(Journal Article): Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers.
Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N
IN:
Mol Med
2000; 6(2):88-95
Impact Factor(s) of Mol Med: 3.576 (2004), 2.656 (2003), 3.234 (2001)
ABSTRACT:
BACKGROUND: Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiat...
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(Journal Article): Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.
Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA
IN:
Dev Biol
2000; 227(2):271-278
Impact Factor(s) of Dev Biol: 5.432 (2004), 5.351 (2003), 5.194 (2002), 5.558 (2001)
ABSTRACT:
Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. ...
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(Journal Article): Insulin production by human embyronic stem cells.
Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL
IN:
Diabetes
2001; 50(8):1-7
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT:
Type 1 diabetes generally results from autoimmune destruction of pancreatic islet beta-cells, with consequent absolute insulin deficiency and complete dependence on exogenous insul...
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