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PDX-1
(Journal Article): Enriched Human Pancreatic Ductal Cultures Obtained from Selective Death of Acinar Cells Express Pancreatic and Duodenal Homeobox Gene-1 Age-Dependently
Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS
IN:
Rev Diabetic Stud
2004; 1(2):66-79
Impact Factor(s) of Rev Diabetic Stud: 0.125 (2006)
ABSTRACT:
Adult pancreatic ductal cells are believed to be islet precursors. Our aim was to obtain an enriched human ductal cell population in defined culture conditions, and to characterize...
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(Journal Article): Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro.
Rooman I, Heremans Y, Heimberg H, Bouwens L
IN:
Diabetologia
2000; 43(7):907-910
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)
ABSTRACT:
AIMS/HYPOTHESIS: In adult pancreatic regeneration models exocrine acini are found to transdifferentiate to duct-like complexes. This has also been associated with the formation of ...
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(Journal Article): Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta-cell identity and function.
Mckinnon CM, Docherty K
IN:
Diabetologia
2001; 44(10):1203-1214
Impact Factor(s) of Diabetologia: 5.583 (2004), 5.689 (2003), 5.136 (2002), 6.299 (2001)
ABSTRACT:
Pancreatic duodenal homeobox -1 is a transcription factor that is expressed in beta and delta cells of the islets of Langerhans and in dispersed endocrine cells of the duodenum. It...
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(Journal Article): Pancreatic duodenal homeobox-1 and islet neogenesis associated protein: a possible combined marker of activateable pancreatic cell precursors.
Gagliardino JJ, Del Zotto H, Massa L, Flores LE, Borelli MI
IN:
J Endocrinol
2003; 177(2):249-259
Impact Factor(s) of J Endocrinol: 3.319 (2004), 3.023 (2003), 2.834 (2001)
ABSTRACT:
The aim of this work was to study the possible relationship between pancreatic duodenal homeobox-1 (Pdx-1) and islet neogenesis-associated protein (INGAP) during induced islet neog...
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(Journal Article): Expansion of PDX-1 expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor-alpha.
Young-Song S, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD
IN:
Gastroenterology
1999; 117(6):1416-1426
Impact Factor(s) of Gastroenterology: 13.092 (2004), 12.718 (2003), 13.44 (2002), 13.02 (2001)
ABSTRACT:
BACKGROUND & AIMS: The progenitor cells responsible for transforming growth factor (TGF)-alpha-induced pancreatic ductal metaplasia and neoplasia remain uncharacterized. During...
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(Journal Article): Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.
Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P
IN:
Diabetes
2001; 50(7):1553-1561
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT:
The homeodomain protein PDX-1 is critical for pancreas development and is a key regulator of insulin gene expression. PDX-1 nullizygosity and haploinsufficiency in mice and humans ...
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(Journal Article): Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin induced hyperglycemia.
Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A
IN:
Nat Med
2000; 6(5):568-572
Impact Factor(s) of Nat Med: 28.878 (2005), 31.223 (2004), 30.55 (2003), 28.74 (2002), 27.906 (2001)
ABSTRACT:
Insulin gene expression is restricted to islet beta cells of the mammalian pancreas through specific control mechanisms mediated in part by specific transcription factors. The prot...
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(Journal Article): Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein IPF-1.
Heimberg H, Bouwens L, Heremans Y, Van den Casteele M, Lefebvre V, Pipeleers D
IN:
Diabetes
2000; 49(4):571-579
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT:
The homeodomain transcription factor encoded by the pancreatic and duodenal homeobox gene-1 (Ipf-1) is essential for pancreatic ontogenesis. Whether Ipf-1 is also involved in the n...
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