Diabetes OD > Development and Function of Pancreas and Immunity > Immune System > Activation and Inhibition > Costimulation > Programmed Death > PD-1	Display all items Journal Articles Discussion Articles Comments Discussions Conferences/Workshops Availabilities Grants/Funds Information/News

Sub-Areas to PD-1:

Peripheral Tolerance (2)

(Journal Article): Structural and functional analysis of the costimulatory receptor programmed death-1.
 
Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC
 
IN: Immunity 2004; 20(3):337-347
Impact Factor(s) of Immunity: 1.545 (2004), 16.016 (2003), 17.468 (2002), 18.866 (2001)

ABSTRACT: PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of ... Click HERE for details

(Journal Article): Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice.
 
Nishimura H, Honjo T, Minato N
 
IN: J Exp Med 2000; 191(5):891-898
Impact Factor(s) of J Exp Med: 14.588 (2004), 15.302 (2003), 15.34 (2001)

ABSTRACT: PD-1 is an immunoglobulin superfamily member bearing an immunoreceptor tyrosine-based inhibitory motif, and disruption of the PD-1 gene results in the development of lupus-like aut... Click HERE for details

(Journal Article): Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
 
Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T
 
IN: Science 2001; 291(5502):319-322
Impact Factor(s) of Science: 30.927 (2005), 31.853 (2004), 29.162 (2003), 26.682 (2002), 23.329 (2001)

ABSTRACT: Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mic... Click HERE for details

(Journal Article): Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
 
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T.
 
IN: J Exp Med 2000; 192(7):1027-1034
Impact Factor(s) of J Exp Med: 14.588 (2004), 15.302 (2003), 15.34 (2001)

ABSTRACT: PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate ... Click HERE for details

(Journal Article): PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
 
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ.
 
IN: Nat Immunol 2001; 2(3):261-268
Impact Factor(s) of Nat Immunol: 27.011 (2005), 27.586 (2004), 28.18 (2003), 27.868 (2002), 17.431 (2001)

ABSTRACT: Programmed death I (PD-I)-deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. We ... Click HERE for details

(Journal Article): Expression of programmed death 1 ligands by murine T cells and APC.
 
Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, Shin T, Tsuchiya H, Pardoll DM, Okumura K, Azuma M, Yagita H
 
IN: J Immunol 2002; 169(10):5538-5545
Impact Factor(s) of J Immunol: 6.486 (2004), 6.702 (2003), 7.065 (2001)

ABSTRACT: Programmed death 1 (PD-1) is a new member of the CD28/CTLA-4 family, which has been implicated in the maintenance of peripheral tolerance. Two ligands for PD-1, namely, B7-H1 (PD-L... Click HERE for details

(Journal Article): Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.
 
Ishida M, Iwai Y, Tanaka Y, Okazaki T, Freeman GJ, Minato N, Honjo T
 
IN: Immunol Lett 2002; 84(1):57-62
Impact Factor(s) of Immunol Lett: 2.136 (2004), 1.71 (2003), 1.847 (2002), 2.009 (2001)

ABSTRACT: PD-1 is a member of the immunoglobulin superfamily expressed on immune cells, including T and B cells, and is involved in the delivery of inhibitory signal upon engagement of its l... Click HERE for details

(Journal Article): Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis.
 
Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ
 
IN: Eur J Immunol 2003; 33(11):3117-3126
Impact Factor(s) of Eur J Immunol: 5.005 (2004), 4.536 (2003), 4.832 (2002), 4.99 (2001)

ABSTRACT: Interactions between CD8+ T cells and endothelial cells are important in both protective and pathologic immune responses. Endothelial cells regulate the recruitment of CD8+ T cells... Click HERE for details

(Journal Article): PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells.
 
Loke P, Allison JP
 
IN: Proc Natl Acad Sci U S A 2003; 100(9):5336-5341
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)

ABSTRACT: PD-L1 and PD-L2 are ligands for PD-1, a costimulatory molecule that plays an inhibitory role in regulating T cell activation in the periphery. We find that PD-L1 is highly expresse... Click HERE for details

(Journal Article): Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
 
Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F
 
IN: J Exp Med 2003; 198(1):31-38
Impact Factor(s) of J Exp Med: 14.588 (2004), 15.302 (2003), 15.34 (2001)

ABSTRACT: B7-DC is a recently discovered member of the B7 family that binds to PD-1 and is selectively expressed by dendritic cells (DCs). It has been shown to either costimulate or inhibit ... Click HERE for details

(Journal Article): Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
 
Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L
 
IN: J Exp Med 2003; 197(9):1083-1091
Impact Factor(s) of J Exp Med: 14.588 (2004), 15.302 (2003), 15.34 (2001)

ABSTRACT: B7-H1 and B7-DC are ligands for PD-1, a receptor implicated in negative regulation of T and B cell functions. These ligands, however, also costimulate T cell responses. It remains ... Click HERE for details