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Peripheral Tolerance
(Journal Article): Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
Nishimura H, Nose M, Hiai H, Minato N, Honjo T
IN:
Immunity
1999; 11(2):141-151
Impact Factor(s) of Immunity: 1.545 (2004), 16.016 (2003), 17.468 (2002), 18.866 (2001)
ABSTRACT:
PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based inhibitory motif, is induced in lymphocytes and monocytic cells following activation. Aged C57BL/6(...
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(Journal Article): PD-1 inhibits antiviral immunity at the effector phase in the liver.
Iwai Y, Terawaki S, Ikegawa M, Okazaki T, Honjo T
IN:
J Exp Med
2003; 198(1):39-50
Impact Factor(s) of J Exp Med: 14.588 (2004), 15.302 (2003), 15.34 (2001)
ABSTRACT:
Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of costimulatory molecules on tissu...
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