(Journal Article): Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.
 
Halban PA (Department of Genetic Medicine and Development, University Medical Centre, 1 rue Michel Servet, 1211 Geneva 4, Switzerland., philippe.halban@medecine.unige.ch )
 
IN: Nat Cell Biol 2004; 6(11):1021-1025
Impact Factor(s) of Nat Cell Biol: 20.649 (2004), 20.268 (2003), 18.285 (2002), 14.739 (2001)

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ABSTRACT: Replacing missing insulin-producing beta cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of beta-cell embryogenesis and regeneration in adult life is needed to devise means to derive these specialized cells in sufficiently large numbers from stem or precursor cells. It is also critical to ensure that any surrogate or regenerated beta cells have perfectly regulated insulin production, which is essential for physiological glucose homeostasis.

TYPE OF PUBLICATION: Review

Articles citing this article:

• Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med 2006. 12: 310-316.
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