Risk of Diabetes

Sub-Areas to Risk of Diabetes:

Embryonic Death (0)
Diabetic Embryopathy/Fetal Growth Pertubations (2)

(Journal Article): Shoulder dystocia--risk factors and fetal outcome
 
[No indication of authors]
 
IN: Akush Ginekol (Sofiia) 2004; 43(4):3-9

ABSTRACT: The purpose of this retrospective study is to evaluate the perinatal outcome in cases with birth injuries, suggesting shoulder dystocia. This survey involves 92 cases of live newborns (gestational age between 37 and 42 weeks) with shoulder injuries. Another control group of 120 cases of live mature newborns without any shoulder injuries is studied for comparison. There are no significant differentialities between those two groups, regarding age, parity, weight and height of the parturients. Shoulder dystocia is most frequently found in newborns of 3500-4000 g birthweight. Antepartum, risk factors for shoulder dystocia are: diabetes, obesity of the mother and chronological postterm pregnancy. Intrapartum, the evaluated risk factors prove to be unreliable because the same were found in as many as one half of the non-traumatic vaginal deliveries. In 27% of the cases, shoulder dystocia occurs most probably after the passage of the shoulder through the pelvic inlet. The most frequent type of shoulder injury is fracture of the clavicle (90.2%), followed by paresis of the brachial plexus (7.6%). Severe shoulder dystocia both from obstetrical and neonatological point of view is found in 2-3% of the cases.

(Journal Article): Long-term postoperative mortality in diabetic patients undergoing major non-cardiac surgery
 
Juul AB, Wetterslev J, Kofoed-Enevoldsen A (Copenhagen University Hospital, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7102, Rigshospitalet, Copenhagen, Denmark, anne.j@ctu.rh.dk )
 
IN: Eur J Anaesthesiol 2004; 21(7):523-529
Impact Factor(s) of Eur J Anaesthesiol: 1.156 (2004), 1.217 (2003), 1.193 (2002), 0.966 (2001)

ABSTRACT: BACKGROUND AND OBJECTIVE: The prognosis of diabetic patients after surgery remains controversial. Some suggest that the rates of death and complications today are almost identical in diabetic and non-diabetic patients within hospital stay or for 30 days postoperatively, whereas others suggest that diabetes still constitutes a major risk factor for both short-term (< or = 30 days) and long-term (> 30 days) patients especially after major cardiac surgery. We examined the long-term postoperative mortality of diabetic patients undergoing major non-cardiac surgery to identify possible perioperative risk factors. METHODS: Data from 179 consecutive diabetic patients, who underwent major non-cardiac surgery at Herlev Hospital, Denmark, during a 12 month period, have been retrospectively analysed. Data were obtained from patient records and from The Danish National Health Register. The main outcome measure was postoperative mortality. Patients were followed for a maximum of 18 months. RESULTS: The median postoperative observation period was 10 months (range 0-18 months). Overall postoperative mortality was 24% (95% confidence interval (CI) 17-31%). One third of the fatalities occurred during the first 30 days. Ischaemic heart disease diagnosed before the operation was associated with an overall postoperative mortality of 44% (95% CI 29-58%), which was significantly (P < 0.03) higher than in diabetic patients without known cardiovascular disease. The major causes of death in 18 out of 39 (46%) patients were diseases of the cardiovascular system. CONCLUSIONS: Diabetic patients undergoing major non-cardiac surgery seem to have a high mortality, often because of cardiovascular death. Future strategies should focus on implementing cardio-protective treatment during the perioperative period.

(Journal Article): Raising a baby with diabetes
 
Roemer JB
 
IN: Diabetes Forecast 2003; 56(11):64-68

ABSTRACT: Not available.

(Journal Article): Polymorphisms of Interleukin-1beta and beta3-Adrenergic Receptor in Japanese Patients With Nonalcoholic Steatohepatitis
 
Nozaki Y, Saibara T, Nemoto Y, Ono M, Akisawa N, Iwasaki S, Hayashi Y, Hiroi M, Enzan H, Onishi S (Department of Gastroenterology and Hepatology (YNo, TS, YNe, MO, NA, SI, SO) and Department of Pathology (YH, MH, HE), Kochi Medical School, Kochi, Japan)
 
IN: Alcohol Clin Exp Res 2004; 28(8):106S-110S
Impact Factor(s) of Alcohol Clin Exp Res: 2.508 (2004), 2.421 (2003), 2.674 (2001)

Fulltext:    HTML 

ABSTRACT: BACKGROUND:: Obesity, hypertriglyceridemia, and diabetes have been reported as frequent complications observed in patients with nonalcoholic steatohepatitis (NASH) in Western countries. The aim of this study was to investigate the genetic predisposition on NASH pathogenesis in the Japanese population. METHODS:: Genotypes of two previously described functional polymorphisms-beta3-adrenergic receptor 190 T/A polymorphism, which results in Trp64Arg (W64R) amino acid replacement, and interleukin-1beta-511 T/C polymorphism in the promoter sequence-were determined in 63 Japanese NASH patients and 100 healthy volunteers using polymerase chain reaction and restriction fragment length polymorphism. RESULTS:: beta3-adrenergic receptor R allele frequency and the R/- (W/R and R/R) genotype frequency were significantly higher in NASH patients than those in control subjects. Interleukin-1beta-511 T allele frequency and the T/T genotype frequency were significantly higher in NASH patients than those in control subjects. Obesity, hypertriglyceridemia, and hyperinsulinemia were associated with NASH patients with the R/- genotype, whereas an increase in fasting plasma glucose level and a decrease in insulinogenic index were associated with NASH patients with the W/W genotype. CONCLUSION:: This study confirmed the contribution of obesity, glucose intolerance, and hypertriglyceridemia to NASH development in the Japanese population. In addition to these factors, genetic predispositions to obesity and inflammation in the Japanese population were shown to contribute much to the development of NASH.