11. (Journal Article): Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets

Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R
 
ABSTRACT: Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead to many clinical benefits if differentiated cell types can be derived from them and u...

12. (Journal Article): Effectiveness of a disease management program for patients with diabetes

Villagra VG, Ahmed T
 
ABSTRACT: Diabetes disease management programs (DDMPs) are proliferating, but their effectiveness in improving quality and mitigating health care spending has been difficult to measure. Usin...

13. (Journal Article): Enhanced insulin secretion and improved glu-cose tolerance in mice lacking CD26.

Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N
 
ABSTRACT: A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC ), specifically cleave off N-terminal dipeptides from substrates having proline or alanine...

14. (Journal Article): The effect of age on insulin resistance and secretion: a review.

Muller DC, Elahi D, Tobin JD, Andres R
 
ABSTRACT: Aging is associated with an increased incidence of hypertension, noninsulin-dependent diabetes mellitus, and coronary heart disease. Because these conditions often cluster in the s...

15. (Journal Article): Neuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse.

Homo-Delarche F
 
ABSTRACT: Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which insulin-producing beta cells of the pancreatic islets of Langerhans are destroyed. The nonobese diabetic (NOD...

16. (Journal Article): Islet Generation from Intra Islet Precursor Cells of Diabetic Pancreas: In Vitro Studies Depicting In Vivo Differentiation

Banerjee M, Bhonde RR
 
ABSTRACT: CONTEXT: Beta-cells have a limited replicative capacity; hence, there is always a quest for sources of islet regeneration to compensate for the loss of functional beta-cells in dia...

17. (Journal Article): A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C
 
ABSTRACT: Previous linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was...

18. (Journal Article): Mucosal Tolerance to Prevent Type 1 Diabetes: Can the Outcome Be Improved in Humans?

Hanninen A, Harrison LC
 
ABSTRACT: The results of trials in which autoantigens have been fed to individuals affected by autoimmune diseases - multiple sclerosis, rheumatoid arthritis and type 1 diabetes - have been ...

19. (Journal Article): ALDH2/ADH2 Polymorphism Associated with Vasculopathy and Neuropathy in Type 2 Diabetes

Suzuki Y, Taniyama M, Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K
 
ABSTRACT: In the history of diabetes, chlorpropamide alcohol flushing test (CPAF) was a big topic in the 1970s to 1980s. Alcohol tolerance after chlorpropamide has prognostic significance, w...

20. (Journal Article): Prevalence of Type 2 Diabetic Patients Within the Targets of Care Guidelines in Daily Clinical Practice: A Multi-Center Study in Brazil

Gomes MB, Gianella D, Faria M, Tambascia M, Fonseca RM, Rea R, Macedo G, Filho JM, Schmid H, Bittencourt AV, Cavalcanti S, Rassi N, Pedrosa H, Dib SA
 
ABSTRACT: Major clinical studies have shown that the targets for blood glucose, lipid profile and blood pressure in type 2 diabetic patients are difficult to maintain in clinical practice. H...