1. (Journal Article): Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese zucker and sprague-dawley rats: implications of decreased glucuronidation in obese zucker rats

Kim MS, Wang S, Shen Z, Kochansky CJ, Strauss JR, Franklin RB, Vincent SH
 
ABSTRACT: Genetically obese Zucker rats exhibit symptoms similar to those of obese patients with insulin-resistance or Type II diabetes; therefore, they have been used as a genetic model to ...

2. (Journal Article): Decreased first-phase secretion of insulin may play a role in the development of insulin resistance.

Wittmann I, Soltesz G, Jermendy G, Nagy J
 
ABSTRACT: Decreased first-phase secretion of insulin may play a role in the development of insulin resistance. In the development of type 2 diabetes an abnormal function of the beta-cells an...