1. (Journal Article): Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential.

Holst JJ
 
ABSTRACT: Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted from endocrine cells in the gut mucosa in response to meal ingestion. It is an important incretin hormone; mic...

2. (Journal Article): Glucagon and other proglucagon-derived peptides. Gut peptides: biochemistry and physiology

Holst JJ, 0rskov C
 
ABSTRACT: n.a.

3. (Journal Article): Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors.

Holst JJ, Deacon CF
 
ABSTRACT: n.a.

4. (Journal Article): GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans.

Schjoldager BT, Mortensen PE, Christiansen J, 0rskov C, Holst JJ
 
ABSTRACT: Glucagon-like peptide 1 amide (GLP-1 amide), a predicted product of the glucagon gene (proglucagon 72-107-amide), and truncated GLP-1 (proglucagon 78-107-amide), recently isolated ...

5. (Journal Article): Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study.

Zander M, Madsbad S, Madsen JL, Holst JJ
 
ABSTRACT: BACKGROUND: Glucagon-like peptide 1 (GLP-1) has been proposed as a treatment for type 2 diabetes. We have investigated the long-term effects of continuous administration of this pe...

6. (Journal Article): Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

Deacon CF, Johnsen AH, Holst JJ
 
ABSTRACT: The metabolism of glucagon-like peptide-1 (GLP-1) has not been studied in detail, but it is known to be rapidly cleared from the circulation. Measurement by RIA is hampered by the ...

7. (Journal Article): Proglucagon processing in porcine and human pan-creas.

Holst JJ, Bersani M, Johnsen AH, Kofod H, Hartmann B, Orskov C
 
ABSTRACT: In the pancreas proglucagon (PG), a peptide precursor of 160 amino acids is cleaved to produce glucagon and a 30-amino acid N-terminal flanking peptide, but the fate of the C-termi...

8. (Journal Article): Pancreatic and intestinal processing of proglucagon in man.

0rskov C, Holst JJ, Poulsen S, Kirkegaard P
 
ABSTRACT: We developed antisera and radioimmunoassays against synthetic replicas of glucagon-like peptide-1 (1-36) and -2, predicted products of the glucagon precursor, and against glucagon-...