1. (Journal Article): Factors influencing Islet of Langerhans graft function and monitoring.

Pileggi A, Ricordi C, Alessiani M, Inverardi L
 
ABSTRACT: Transplantation of islet of Langerhans represents a viable therapeutic option for insulin-dependent diabetes mellitus. Dramatic progress has been recently reported with the introdu...

2. (Journal Article): Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation.

Moberg L, Johansson H, Lukinius A, Berne C, Foss A, Kallen R, Ostraat O, Salmela K, Tibell A, Tufveson G, Elgue G, Nilsson Ekdahl K, Korsgren O, Nilsson B
 
ABSTRACT: BACKGROUND: Intraportal transplantation of pancreatic islets offers improved glycaemic control and insulin independence in type 1 diabetes mellitus, but intraportal thrombosis rema...

3. (Journal Article): Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.

Klein D, Ribeiro MM, Mendoza V, Jayaraman S, Kenyon NS, Pileggi A, Molano RD, Inverardi L, Ricordi C, Pastori RL
 
ABSTRACT: Viability of isolated islets is one of the main obstacles limiting islet transplantation success. It has been reported that overexpression of Bcl-2/Bcl-XL proteins enhances islet v...

4. (Journal Article): Effect of oxygen levels in villous trophoblast apoptosis.

Kilani RT, Mackova M, Davidge ST, Guilbert LJ
 
ABSTRACT: In pregnancies complicated by intrauterine growth restriction (IUGR), the villous trophoblast shows increased apoptosis and immature cytotrophoblasts (CT) may be exposed to both hi...

5. (Journal Article): Nestin expression in pancreatic exocrine cell lineages.

Delacour A, Nepote V, Trumpp A, Herrera PL
 
ABSTRACT: Expression of nestin has been suggested to be a characteristic of pancreatic islet stem cells. To determine whether nestin is indeed expressed in such putative cells during embryon...

6. (Journal Article): Phosphatidylinositol 3-kinase signaling to Akt mediates survival in isolated canine islets of Langerhans.

Aikin R, Rosenberg L, Maysinger D
 
ABSTRACT: The isolation of islet cells from the pancreas by enzymatic digestion causes many of these cells to undergo apoptosis. The aim of this work was to investigate the role of phosphati...

7. (Journal Article): Pancreas preservation by the two layer cold storage method before islet isolation protects isolated islets against apoptosis through the mitochondrial pathway.

Matsuda T, Suzuki Y, Tanioka Y, Toyama H, Kakinoki K, Hiraoka K, Fujino Y, Kuroda Y
 
ABSTRACT: BACKGROUND: Apoptosis in isolated islets has been implicated in primary nonfunction or early graft failure after islet transplantation. Recently, pancreas preservation by the 2-lay...

8. (Journal Article): Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.

Ishida M, Iwai Y, Tanaka Y, Okazaki T, Freeman GJ, Minato N, Honjo T
 
ABSTRACT: PD-1 is a member of the immunoglobulin superfamily expressed on immune cells, including T and B cells, and is involved in the delivery of inhibitory signal upon engagement of its l...

9. (Journal Article): Complementary therapies and diabetes

Dunning T
 
ABSTRACT: There is increasing recognition that people with diabetes use a range of complementary therapies (CT), for a number of conditions, but do not always inform their conventional healt...