Progenitors
Sub-Areas to Progenitors:
Derived from Adult Islet Cells
(2)
Pancreatic Epithelial Cells
(7)
Differentiation
(1)
Transdifferentiation
(2)
Insulinotropic Substances
(1)
(Journal Article): Insulin-Producing Cells from Tissue Stem/Progenitor Cells: Are Autologous Cells Preferable to Allogeneic?
Efrat S
IN:
Rev Diabetic Stud
2005; 2(1):3-8
Impact Factor(s) of Rev Diabetic Stud: 0.125 (2006)
ABSTRACT:
Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet insulin-producing β-cells. Insulin administration does not prevent long-term complications of the disea...
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(Journal Article): Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R
IN:
Science
2001; 292:1389-1394
Impact Factor(s) of Science: 30.927 (2005), 31.853 (2004), 29.162 (2003), 26.682 (2002), 23.329 (2001)
ABSTRACT:
Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead to many clinical benefits if differentiated cell types can be derived from them and u...
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(Journal Article): Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.
Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK
IN:
Proc Natl Acad Sci USA
2002; 99:16105-16110
ABSTRACT:
The use of embryonic stem cells for cell-replacement therapy in diseases like diabetes mellitus requires methods to control the development of multipotent cells. We report that tre...
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(Journal Article): Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells.
Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L, Wobus AM
IN:
Proc Natl Acad Sci U S A
2003; 100:998-1003
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)
ABSTRACT:
Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers including endodermal cells that produce insulin in vitro. We show that constitutive expres...
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(Journal Article): In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.
Ianus A, Holz GG, Theise ND, Hussain MA
IN:
J Clin Invest
2003; 111(6):843-850
Impact Factor(s) of J Clin Invest: 14.204 (2004), 14.307 (2003), 14.118 (2001)
ABSTRACT:
Bone marrow harbors cells that have the capacity to differentiate into cells of nonhematopoietic tissues of neuronal, endothelial, epithelial, and muscular phenotype. Here we demon...
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(Journal Article): Bone marrow-derived stem cells initiate pancreatic regeneration.
Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, Thyssen S, Gray DA, Bhatia M
IN:
Nat Biotechnol
2003; 21(7):763-770
Impact Factor(s) of Nat Biotechnol: 22.738 (2005), 22.355 (2004), 17.721 (2003), 12.822 (2002), 11.31 (2001)
ABSTRACT:
We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although quantitative ...
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(Journal Article): Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.
Kojima H, Nakamura T, Fujita Y, Kishi A, Fujimiya M, Yamada S, Kudo M, Nishio Y, Maegawa H, Haneda M, et al
IN:
Diabetes
2002; 51:1398-1408
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT:
Immature rat intestinal stem cells (IEC-6) given the ability to express the transcription factor, pancreatic duodenal homeobox 1 (Pdx-1), yielded YK cells. Although these cells pro...
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(Journal Article): NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.
Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L
IN:
Nat Med
2003; 9(5):596-603
Impact Factor(s) of Nat Med: 28.878 (2005), 31.223 (2004), 30.55 (2003), 28.74 (2002), 27.906 (2001)
ABSTRACT:
To explore induced islet neogenesis in the liver as a strategy for the treatment of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the pancreatic duodenal homeobox...
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(Journal Article): Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.
Zalzman M, Gupta S, Giri R, Berkovich I, Sappal BS, Karnieli O, Zern MA, Fleischer N, Efrat S
IN:
Proc Natl Acad Sci U S A
2003; 100(12):7253-7258
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)
ABSTRACT:
Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a large scale is hindered by a shortage of cells for tran...
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(Journal Article): Cell replacement therapy for type 1 diabetes.
Efrat S
IN:
Trends Mol Med
2002; 8(7):334-339
Impact Factor(s) of Trends Mol Med: 7.497 (2004), 9.848 (2003), 7.162 (2002)
ABSTRACT:
Replacement of the insulin-producing pancreatic islet beta cells represents the ultimate treatment for type 1 diabetes. Recent advances in islet transplantation underscore the urge...
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(Journal Article): Encapsulated, genetically modified cells producing in vivo therapeutics.
Hauser O, Prieschl-Grassauer E, Salmons B
IN:
Curr Opin Mol Ther
2004; 6:412-420
Impact Factor(s) of Curr Opin Mol Ther: 3.117 (2004), 3.049 (2003), 2.463 (2002), 1.148 (2001)
ABSTRACT:
The ability to implant genetically modified cells in immuno-isolating materials has much potential for therapeutic use. This review presents the different types of polymer that can...
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(Journal Article): A second pathway for regeneration of adult exocrine and endocrine pancreas.
Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE
IN:
Diabetes
1993; 42(12):1715-1720
Impact Factor(s) of Diabetes: 8.848 (2004), 8.298 (2003), 8.256 (2002), 7.7 (2001)
ABSTRACT:
Substantial regeneration of both the endocrine and exocrine pancreas occurs after a 90% partial pancreatectomy in the young adult rat. We have reported previously that replication ...
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