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Diabetes Open Directory


At this place you will find news about current research results, imminent conferences and approaching presentations. This page shows the 10 latest Contributions to DOD. You may wish to restrict your search to specific items:


1. (Journal Article): Prediction and pathogenesis in type 1 diabetes

Ziegler AG, Nepom GT
ABSTRACT: A combination of genetic and immunological features is useful for prediction of autoimmune diabetes. Patterns of immune response correspond to the progression from a preclinical ph...




2. (Journal Article): Gamma subunit of voltage-activated calcium channels.

Kang MG, Campbell KP
ABSTRACT: Voltage-activated Ca2+ channels play a major role in many fundamental physiological processes including neurotransmission, muscle contraction, intracellular signaling, hormone secr...




3. (Journal Article): Auxiliary subunits: essential components of the voltage-gated calcium channel complex

Arikkath J, Campbell KP
ABSTRACT: Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the chann...




4. (Journal Article): Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets.

Abernethy DR, Soldatov NM
ABSTRACT: The L-type Ca2+ channels mediate depolarization-induced influx of Ca2+ into a wide variety of cells and thus play a central role in triggering cardiac and smooth muscle contraction...




5. (Journal Article): Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.

Ivanov SV, Ward JM, Tessarollo L, McAreavey D, Sachdev V, Fananapazir L, Banks MK, Morris N, Djurickovic D, Devor-Henneman DE, Wei MH, Alvord GW, Gao B, Richardson JA, Minna JD, Rogawski MA, Lerman MI
ABSTRACT: CACNA2D2 is a putative tumor suppressor gene located in the human chromosome 3p21.3 region that shows frequent allelic imbalances in lung, breast, and other cancers. The alpha2delt...




6. (Journal Article): Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR
ABSTRACT: The calcium channel alpha2delta-1 subunit is a structural subunit important for functional calcium channel assembly. In vitro studies have shown that this subunit is the binding si...




7. (Journal Article): Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.

Marais E, Klugbauer N, Hofmann F
ABSTRACT: High-voltage activated calcium channels are modulated by a series of auxiliary proteins, including those of the alpha(2)delta family. Until recently, only a single alpha(2)delta su...




8. (Journal Article): Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.

Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH
ABSTRACT: 1. This study examined the action of gabapentin (gabapentin,1-(aminomethyl) cyclohexane acetic acid (Neurontin) on voltage-gated calcium (Ca(2+)) channel influx recorded in culture...




9. (Journal Article): Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.

Varadi G, Lory P, Schultz D, Varadi M, Schwartz A
ABSTRACT: The L-type voltage-dependent calcium channel is an important link in excitation-contraction coupling of muscle cells (reviewed in refs 2 and 3). The channel has two functional char...




10. (Journal Article): Molecular basis for Ca2+ channel diversity.

Hofmann F, Biel M, Flockerzi V