(Journal Article): Components of total measurement error for hemoglobin A(1c) determination.
 
Phillipov G, Phillips PJ (Endocrinology, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia., george.phillipov(at)nwahs.sa.gov.au )
 
IN: Clin Chem 2001; 47(10):1851-1853
Impact Factor(s) of Clin Chem: 6.501 (2004), 5.538 (2003), 4.788 (2002), 4.371 (2001)

Fulltext:    HTML  PDF

ABSTRACT: The Diabetes Control and Complications Trial (DCCT) and the UK Prospective Diabetes Study (UKPDS), undertaken in people with type 1 and 2 diabetes, respectively, established the significance of glycohemoglobin (gHb), and in particular hemoglobin A1c (HbA1c), as a prognostic indicator for long-term micro- and macrovascular complications. However, the HbA1c measured during the DCCT and UKPDS represents a gHb fraction characterized by its retention time on cation-exchange HPLC rather than its unique chemical structure (deoxyfructosylhemoglobin). Accordingly, the DCCT HbA1c procedure represents a selective, but not a specific assay method .

TYPE OF PUBLICATION: Original article

Articles citing this article:

• Phillips P. Type 2 Diabetes – Failure, Blame and Guilt in the Adoption of Insulin Therapy. Rev Diabetic Stud 2005. 2: 35-39.
  » Diabetes OD » Disease Management » T2DM » Adoption of Insulin Therapy » Psychological Insulin Resistan... » Journal Article