(Journal Article): Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population.
 
Tan MS, Chang SY, Chang DM, Tsai JC, Lee YJ
 
IN: J Clin Endocrinol Metab 2003; 88:1258-1263
Impact Factor(s) of J Clin Endocrinol Metab: 5.778 (2004), 5.873 (2003), 5.16 (2001)

Fulltext:    HTML  PDF

ABSTRACT: Resistin, a recently discovered polypeptide, antagonizes insulin action and may play a part in the pathogenesis of insulin resistance. This study investigates whether resistin gene polymorphism can be associated with type 2 diabetes. We studied 1102 Chinese type 2 diabetes patients and 743 subjects without diabetes. The resistin 3'-untranslated region (UTR) +62G->A polymorphism was determined by PCR. Type 2 diabetes subjects had a lower frequency of resistin gene 3'UTR +62A allele (GG:GA/AA, 83.5%:16.5%) than the controls (GG:GA/AA, 75.1%:24.9%; odds ratio, 1.524; 95% confidence interval, 1.268-1.831; P < 0.001). Unexpectedly, diabetic patients with the GG genotype had a higher prevalence of hypertension (GG:GA/AA, 49.8%:36.2%; odds ratio, 1.375; 95% confidence interval, 1.116-1.693; P = 0.001). Logistic regression analysis confirmed that the resistin gene 3'UTR +62G->A polymorphism acts as an independent contributing factor to type 2 diabetes and hypertension. The mean systolic and diastolic blood pressure levels in diabetic subjects with the GG genotype (144 ± 21/87 ± 13 mm Hg) were significantly higher than those in subjects with GA/AA variants (139 ± 21/84 ± 14 mm Hg; P = 0.004 and P = 0.002, respectively). Multiple linear regression analysis showed resistin gene polymorphism to be an independent factor associated with systolic and diastolic blood pressures in type 2 diabetes patients. These findings suggest that resistin may play a role in the pathogenesis of type 2 diabetes and insulin resistance-related hypertension.

TYPE OF PUBLICATION: Original article

REFERENCES:

1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 2001. 409:307-312.
2. Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 2002. 13:18-23.
3. McTernan CL, McTernan PG, Harte AL, Levick PL, Barnett AH, Kumar S. Resistin, central obesity, and type 2 diabetes. Lancet 2002. 359:46-47.
4. Nagaev I, Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 2001. 285:561-564.
5. Janke J, Engeli S, Gorzelniak K, Luft FC, Sharma AM Resistin gene expression in human adipocytes is not related to insulin resistance. Obes Res 2002. 10:1-5.
6. Savage DB, Sewter CP, Llenkm ES, Segal DG, Vidal-Puig A, Considine RV, O’Rahilly S. Resistin/Fizz3 expression in relation to obesity and peroxisime proliferator-activated receptor-{gamma} action in humans. Diabetes 2001. 50:2199-2202.
7. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988. 37:1595-1607.
8. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Cardiovascular risk factors in confirmed pre-diabetic individuals: does the clock for coronary artery disease start ticking before the onset of clinical diabetes? JAMA 1990. 263:2893-2898.
9. Cao H, Hegele RA. Single nucleotide polymorphisms of the resistin (RSTN) gene. J Hum Genet 2001. 46:553-555.
10. Pesole G, Mignone F, Gissi C, Grillo G, Licciulli F, Liuni S. Structural and functional features of eukaryotic mRNA untranslated regions. Gene 2001. 276:73-81.
11. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabet Med 1998. 15:539-553.
12. Lee YJ, Tsai JC. ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care 2002. 25:1002-1008.
13. Lee YJ, Tsai JC. Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. Metabolism 2001. 50: 1346-1350.
14. Jupe ER, Badgett AA, Neas BR, Craft MA, Mitchell DS, Resta R, Mulvihill JJ, Aston CE, Thompson LF. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Lancet 2001. 357:1588-1589.
15. Wong PM, Yuan Q, Chen H, Sultzer BM, Chung SW. A single point mutation at the 3'-UTR of Ran mRNA leads to profound changes in lipopolysaccharide endotoxin-mediated responses. J Biol Chem 2001. 276:33129-33138.
16. Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kata K, Shimizu I, Fujii Y, Ohashi J, Makino H. Systemic search for single nucleotide polymorphisms in the resistin gene: the absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes. Diabetes 2002. 51:863-866.
17. Sentinelli F, Romeo S, Arca M, Filippi E, Leonetti F, Banchieri M, DiMario U, Baroni MG. Human resistin gene, obesity, and type 2 diabetes: mutation analysis and population study. Diabetes 2002. 51:860-862.
18. Ma X, Warram JH, Trischitta V, Doria A. Genetic variations at the resistin locus and risk of type 2 diabetes in Caucasians. J Clin Endocrinol Metab 2002. 87:4407-4410.
19. Wang H, Chu WS, Hemphill C, Elbein SC. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab 2002. 87:2520-2524.
20. Pizzuti A, Argiolas A, Di Paola R, Baratta R, Rauseo A, Bozzali M, Vigneri R, Dallapiccola B, Trischitta V, Frittitta L. An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. J Clin Endocrinol Metab 2002. 87:4403-4406.
21. Laakso M, Edelman SV, Breechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992. 41:1076-1073.
22. Heise T, Magnusson K, Heinemann L, Sawicki PT. Insulin resistance and the effect of insulin on blood pressure in essential hypertension. Hypertension 1998. 32:243-248.
23. Tack CJ, Ong MK, Lutterman JA, Smits P. Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone. Diabetologia 1998. 41:569-576.
24. Yoshioka S, Nishino H, Shiraki T, Ikeda K, Koike H, Okuno A, Wada M, Fujiwara T, Horikoshi H. Antihypertensive effects of CS-045 treatment in obese Zucker rats. Metabolism 1993. 42:75-80.
25. Buckanan TA, Meehan WP, Jeng YY, Tang D, Chan TM, Nadler J, Scott S, Rude RK, Hsueh WA. Blood pressure lowering by Pioglitazone: evidence for a direct vascular effect. J Clin Invest 1995. 96:354-360.
26. Walker AB, Chattington PD, Buckingham RE, Williams G. The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes 1999. 48:1448-1453.
27. Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994. 331:1188-1193.
28. Ogihara T, Rakugi H, Ikegami H, Mikami H, Masuo K. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am J Hypertens 1995. 8:316-320.
29. Lewis GF, Carpenter A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002. 23:201-229.
30. Ravussin E, Smith SR. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann NY Acad Sci 2002. 967:363-378.
31. Kim KH, Lee K, Moon YS, Sul HS. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 2001. 276:11252-11256.
32. Montani JP, Antic V, Yang Z, Dulloo A. Pathways from obesity to hypertension: from the perspective of a vicious triangle. Int J Obes Relat Metab Disord 2002. 26(Suppl 2):S28-S38.
33. Ferrari P, Weidmann P. Insulin, insulin sensitivity and hypertension. J Hypertens 1990. 8:491-500.

Articles citing this article:

• Tsai JCR, Chang DM, Chung FM, Wu JC, Shin SJ, Lee YJ. The Association of Silent Coronary Artery Disease and Metabolic Syndrome in Chinese with Type 2 Diabetes Mellitus. Rev Diabetic Stud 2004. 1: 18-28.
  » Diabetes OD » Diabetic Complications » T2DM » Cardiovascular » Coronary Artery Disease » Journal Article