(Journal Article): Manganese superoxide dismutase gene polymorphism and schizophrenia: relation to tardive dyskinesia.
 
Hori H, Ohmori O, Shinkai T, Kojima H, Okano C, Suzuki T, Nakamura J (Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.)
 
IN: Neuropsychopharmacology 2000; 23(2):170-177
Impact Factor(s) of Neuropsychopharmacology: 4.941 (2004), 5.201 (2003), 4.715 (2001)

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ABSTRACT: There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia and/or tardive dyskinesia (TD). In the present study, we investigated the genetic association between a functional polymorphism (Ala-9Val) in the human manganese (Mn) SOD gene and schizophrenia or TD (192 schizophrenics: 39 with TD and 153 without TD; 141 controls). No significant differences in the allelic or genotypic distribution between schizophrenics and controls were observed. However, we did find a significant difference in genotypic distribution between schizophrenics with and those without TD (p =. 03). Moreover, decreased -9Ala (mutant) allele was found among patients with TD (p =.02; odds ratio = 0.29; 95% confidence interval = 0.10-0.83). In conjunction with previous findings of increased free radicals and decreased SOD activities in TD subjects, these results suggest that the -9Ala (high activity) MnSOD allele may play a role in protecting against susceptibility to TD in schizophrenics.

TYPE OF PUBLICATION: Original article

Articles citing this article:

• El Masry TM, Abou Zahra MA, El Tawil MM, Khalifa RA. Manganese Superoxide Dismutase Alanine to Valine Polymorphism and Risk of Neuropathy and Nephropathy in Egyptian Type 1 Diabetic Patients. Rev Diabetic Stud 2005. 2: 70-74.
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