Virus Infection

(Journal Article): Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice.
 
Ohashi PS, Oehen S, Buerki K, Pircher H, Ohashi CT, Odermatt B, Malissen B, Zinkernagel RM, Hengartner H (Department of Experimental Pathology, University Hospital, Zurich, Switzerland.)
 
IN: Cell 1991; 65(2):305-317
Impact Factor(s) of Cell: 29.431 (2005), 26.626 (2003), 27.254 (2002), 29.219 (2001)

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ABSTRACT: To address the mechanisms of tolerance to extrathymic proteins, we have generated transgenic mice expressing the lymphocytic choriomeningitis viral (LCMV) glycoprotein (GP) in the beta islet cells of the pancreas. The fate of LCMV GP-specific T cells was followed by breeding the GP transgenic mice with T cell receptor transgenic mice, specific for LCMV and H-2Db. These studies suggest that "peripheral tolerance" of self-reactive T cells does not involve clonal deletion, clonal anergy, or a decrease in the density of T cell receptors or accessory molecules. Instead, this model indicates that self-reactive cytotoxic T cells may remain functionally unresponsive, owing to a lack of appropriate T cell activation. Infection of transgenic mice with LCMV readily abolishes peripheral unresponsiveness to the self LCMV GP antigen, resulting in a CD8+ T cell-mediated diabetes. These data suggest that similar mechanisms may operate in several so-called "T cell-mediated autoimmune diseases."

TYPE OF PUBLICATION: Original article

Articles citing this article:

• Thomas D, Zaccone P, Cooke A. The Role of Regulatory T Cell Defects in Type I Diabetes and the Potential of these Cells for Therapy. Rev Diabetic Stud 2005. 2: 9-18.
  » Diabetes OD » Reversal/Prevention of Diabete... » T1DM » Re-establishing Tolerance » Modifying Immunity » Journal Article 

(Journal Article): Infection and autoimmunity: are we winning the war, only to lose the peace?
 
Cooke A, Zaccone P, Raine T, Phillips JM, Dunne DW (Pathology Department, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK, ac(at)mole.bio.cam.ac.uk )
 
IN: Trends Parasitol 2004; 20:316-321
Impact Factor(s) of Trends Parasitol: 5.497 (2004), 6.788 (2003), 5.375 (2002)

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ABSTRACT: Not available

TYPE OF PUBLICATION: Original article